Tous les ebooks de la collection "Methods & Principles in Medicinal Chemistry" - Wiley-VCH

78 Livre(s)


Ajouter à ma liste d'envies Molecular Descriptors for Chemoinformatics Viviana Consonni , Roberto Todeschini Molecular Descriptors for Chemoinformatics As every chemist knows, there is a direct (if complex) relationship between the molecular structure of a compound and its chemical behavior. Predicting such behavior is possible by an abstract representation of its structure in... Editeur : Wiley-VCH Parution : 2009-10-30 Collection : Methods & Principles in Medicinal Chemistry PDF 432,50 €
Ajouter à ma liste d'envies Drug Bioavailability Bernard Testa , Han Van De Waterbeemd Drug Bioavailability In order to reach its intended site of action, the drug molecules in every pill that we swallow must first be absorbed, transported via the bloodstream and evade various mechanisms that eliminate drugs from the body. Those drug properties that... Editeur : Wiley-VCH Parution : 2009-09-18 Collection : Methods & Principles in Medicinal Chemistry PDF 248,93 €
Ajouter à ma liste d'envies Transporters as Drug Carriers Peter Chiba , Gerhard F. Ecker This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins... Editeur : Wiley-VCH Parution : 2009-09-03 Collection : Methods & Principles in Medicinal Chemistry PDF 218,33 €
Ajouter à ma liste d'envies Combinatorial Chemistry Willi Bannwarth , Eduard Felder As we enter the new millennium, combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility... Editeur : Wiley-VCH Parution : 2009-08-14 Collection : Methods & Principles in Medicinal Chemistry PDF 161,36 €
Ajouter à ma liste d'envies Drug-Membrane Interactions Joachim K. Seydel , Michael Wiese Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore... Editeur : Wiley-VCH Parution : 2009-07-10 Collection : Methods & Principles in Medicinal Chemistry PDF 119,21 €
Ajouter à ma liste d'envies Virtual Screening for Bioactive Molecules Hans-Joachim Böhm , Gisbert Schneider Recent progress in high-throughput screening, combinatorial chemistry and molecular biology has radically changed the approach to drug discovery in the pharmaceutical industry. New challenges in synthesis result in new analytical methods. At present, typically 100,000... Editeur : Wiley-VCH Parution : 2008-11-21 Collection : Methods & Principles in Medicinal Chemistry PDF 147,65 €
Ajouter à ma liste d'envies Evolutionary Algorithms in Molecular Design David E. Clark When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the 'survival of the fittest',... Editeur : Wiley-VCH Parution : 2008-11-21 Collection : Methods & Principles in Medicinal Chemistry PDF 147,65 €
Ajouter à ma liste d'envies Structure-based Ligand Design Hans-Joachim Böhm , Klaus Gubernator Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a... Editeur : Wiley-VCH Parution : 2008-11-21 Collection : Methods & Principles in Medicinal Chemistry PDF 125,23 €
Ajouter à ma liste d'envies Advanced Computer-Assisted Techniques in Drug Discovery Han Van De Waterbeemd The use of powerful computers has revolutionized molecular design and drug discovery. Thoroughly researched and well-structured, this comprehensive handbook covers highly effective and efficient techniques in 3D-QSAR and advanced statistical analysis.The emphasis is on... Editeur : Wiley-VCH Parution : 2008-09-26 Collection : Methods & Principles in Medicinal Chemistry PDF 125,23 €
Ajouter à ma liste d'envies Lipophilicity in Drug Action and Toxicology Vladimir Pliska , Bernard Testa , Han Van De Waterbeemd In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts. It offers a thorough and highly topical survey of this rapidly developing field of research. Color... Editeur : Wiley-VCH Parution : 2008-09-26 Collection : Methods & Principles in Medicinal Chemistry PDF 116,00 €
Ajouter à ma liste d'envies Nuclear Receptors as Drug Targets Eckhard Ottow , Hilmar Weinmann Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized... Editeur : Wiley-VCH Parution : 2008-09-08 Collection : Methods & Principles in Medicinal Chemistry PDF 242,60 €
Ajouter à ma liste d'envies Protein Crystallography in Drug Discovery Sherin S. Abdel-Meguid , Robert E. Babine The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited... Editeur : Wiley-VCH Parution : 2008-07-15 Collection : Methods & Principles in Medicinal Chemistry PDF 153,98 €
Ajouter à ma liste d'envies Molecular Modeling Gerd Folkers , Hans-Dieter Höltje Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations. Its main objective is the description of the various... Editeur : Wiley-VCH Parution : 2008-07-11 Collection : Methods & Principles in Medicinal Chemistry PDF 134,99 €
Ajouter à ma liste d'envies Handbook of Molecular Descriptors Viviana Consonni , Roberto Todeschini Quantitative studies on structure-activity and structure-property relationships are powerful tools in directed drug research. In recent years, various strategies have been developed to characterize and classify structural patterns by means of molecular descriptors. It... Editeur : Wiley-VCH Parution : 2008-07-11 Collection : Methods & Principles in Medicinal Chemistry PDF 281,63 €
Ajouter à ma liste d'envies Chemometric Methods in Molecular Design Han Van De Waterbeemd The statistical analysis of experimental and theoretical data lies at the heart of modern drug design. This practice-oriented handbook is a comprehensive account of modern chemometric methods in molecular design. It presents strategies for making more rational choices... Editeur : Wiley-VCH Parution : 2008-07-11 Collection : Methods & Principles in Medicinal Chemistry PDF 125,23 €
Ajouter à ma liste d'envies QSAR Hugo Kubinyi Finding the new remedy for a certain disease: an inspired goal. QSAR, an invaluable tool in drug design, aids scientists to attain this aim. This book is a long-awaited comprehensive text to QSAR and related approaches. It provides a practice-oriented introduction to... Editeur : Wiley-VCH Parution : 2008-07-11 Collection : Methods & Principles in Medicinal Chemistry PDF 113,31 €
Ajouter à ma liste d'envies Molecular Drug Properties Raimund Mannhold This first systematic overview for more than a decade is tailor-made for the medicinal chemist. All the chapters are written by experienced drug developers and include practical examples from real drug candidates. Following an introduction to global drug properties and... Editeur : Wiley-VCH Parution : 2008-06-25 Collection : Methods & Principles in Medicinal Chemistry PDF 229,94 €
Ajouter à ma liste d'envies Antitargets Thomas Klabunde , Roy J. Vaz This practice-oriented handbook surveys current knowledge on the prediction and prevention of adverse drug reactions related to off-target activity of small molecule drugs. It is unique in collating the current approaches into a single source, and includes several... Editeur : Wiley-VCH Parution : 2008-04-09 Collection : Methods & Principles in Medicinal Chemistry PDF 216,22 €
Ajouter à ma liste d'envies Chirality in Drug Research Eric Francotte , Wolfgang Lindner Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a... Editeur : Wiley-VCH Parution : 2007-09-24 Collection : Methods & Principles in Medicinal Chemistry PDF 225,72 €
Ajouter à ma liste d'envies Mass Spectrometry in Medicinal Chemistry Georg Höfner , Klaus Wanner This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of... Editeur : Wiley-VCH Parution : 2007-06-27 Collection : Methods & Principles in Medicinal Chemistry PDF 242,60 €
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